Understanding how genes respond to low oxygen in kidney cells
A systems biology approach to identify cortical and medullary gene regulatory networks related to Hypoxia Inducible Factor-1A
This study is looking at how certain genes in kidney cells react to low oxygen levels, which can happen during kidney problems, to help us understand acute kidney injury better and find new ways to treat it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11052788 on NIH RePORTER |
What this research studies
This research investigates the gene regulatory networks in kidney cells, particularly focusing on how these genes respond to low oxygen levels, a condition known as hypoxia. By analyzing kidney samples from patients, the study aims to identify specific transcription factors that work alongside Hypoxia Inducible Factor-1A (HIF1A) to regulate gene expression in both the kidney cortex and medulla. The approach involves advanced techniques to gather and analyze multiome data, which includes both genomic and epigenomic information. This research could lead to a better understanding of acute kidney injury and its underlying mechanisms, potentially paving the way for new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include hospitalized patients who are at risk of or have experienced acute kidney injury, particularly those with conditions leading to hypoxia.
Not a fit: Patients with chronic kidney disease or those who do not have acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for acute kidney injury, potentially reducing mortality and enhancing recovery for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in response to hypoxia, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Schaub, Jennifer Ann — University of Michigan at Ann Arbor
- Study coordinator: Schaub, Jennifer Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.