Understanding how genes on the X chromosome affect diseases that impact women more than men
Genetic regulation of genes on active and inactive X chromosome and their contribution to sex-biased diseases
This study is looking at how genes on the X chromosome might play a role in autoimmune diseases like lupus, which tend to affect women more than men, to help find better treatments for those conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10910881 on NIH RePORTER |
What this research studies
This research investigates the role of the X chromosome in sex-biased diseases, particularly focusing on autoimmune diseases like lupus that disproportionately affect women. The study aims to understand how certain genes on the X chromosome are regulated and how some escape inactivation, potentially influencing disease susceptibility. By examining genetic variations and their effects on gene expression in different tissues, the research seeks to uncover the genetic factors that contribute to these conditions. Patients may benefit from insights that could lead to better-targeted treatments for diseases that affect women more significantly.
Who could benefit from this research
Good fit: Ideal candidates for this research include women diagnosed with autoimmune diseases, particularly those with a family history of such conditions.
Not a fit: Patients who do not have autoimmune diseases or those who are male may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for autoimmune diseases that disproportionately affect women.
How similar studies have performed: Previous research has indicated that understanding X chromosome biology can provide valuable insights into sex-biased diseases, suggesting that this approach has potential for success.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Markus, Havell — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Markus, Havell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.