Understanding how genes on the X chromosome affect diseases that impact women more than men
Official title: Genetic regulation of genes on active and inactive X chromosome and their contribution to sex-biased diseases
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10910881 · Data updated 2026-11-12
This study is looking at how genes on the X chromosome might play a role in autoimmune diseases like lupus, which tend to affect women more than men, to help find better treatments for those conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $34,800 |
| NIH project number | 5F30GM151848-02 |
| Project ID | NIH-10910881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women diagnosed with autoimmune diseases, particularly those with a family history of such conditions.
✕Less likely to help
Patients who do not have autoimmune diseases or those who are male may not receive direct benefits from this research.
What this research studies
This research investigates the role of the X chromosome in sex-biased diseases, particularly focusing on autoimmune diseases like lupus that disproportionately affect women. The study aims to understand how certain genes on the X chromosome are regulated and how some escape inactivation, potentially influencing disease susceptibility. By examining genetic variations and their effects on gene expression in different tissues, the research seeks to uncover the genetic factors that contribute to these conditions. Patients may benefit from insights that could lead to better-targeted treatments for diseases that affect women more significantly.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for autoimmune diseases that disproportionately affect women.
How similar studies have gone: Previous research has indicated that understanding X chromosome biology can provide valuable insights into sex-biased diseases, suggesting that this approach has potential for success.
Where this research is happening
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Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Markus, Havell — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Markus, Havell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.