Understanding how genes in brain cells respond to activity and experiences
Elucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neurons
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10770989
This study is looking at how brain cells change their genes based on what we do and experience, which helps us understand how memories are formed, and it could provide helpful information for people with conditions like bipolar disorder.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10770989 on ClinicalTrials.gov |
What this research studies
This research investigates how neurons in the brain change their gene expression in response to various activities and experiences. By examining the 3-D structure of the genome and how it interacts with epigenetic factors, the team aims to uncover the mechanisms behind synaptic plasticity, which is crucial for memory formation. The study employs advanced techniques in genome folding, chromatin engineering, and neurobiology to explore these complex interactions. Patients may benefit from insights into how these processes relate to conditions like bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bipolar disorder or related mood disorders.
Not a fit: Patients with neurological conditions unrelated to mood disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bipolar disorder and other brain-related conditions by enhancing our understanding of gene regulation in neurons.
How similar studies have performed: Previous research has shown promising results in understanding gene expression related to brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHILLIPS-CREMINS, JENNIFER ELIZABETH — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: PHILLIPS-CREMINS, JENNIFER ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bipolar affective disorder, bipolar disease, manic depressive disorder, Bipolar Disorder, Brain Disorders