Understanding how genes control heart development and function
Official title: Transcriptional control of endocardial-specific gene expression
Funded at University of California, San Francisco · NIH-11027543 · Data updated 2026-11-12
This study is looking at how certain genes help shape the inner lining of the heart, which could help us understand why some people are born with heart problems or develop heart issues later in life, and it hopes to find new ways to treat or prevent these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $540,856 |
| NIH project number | 1R01HL177462-01 |
| Project ID | NIH-11027543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with congenital heart disease or those at risk for cardiovascular conditions due to genetic factors.
✕Less likely to help
Patients with heart conditions unrelated to genetic factors or those without congenital heart disease may not receive direct benefits from this research.
What this research studies
This research investigates the genetic mechanisms that regulate the development and function of the endocardium, the inner lining of the heart. By examining how these genes are expressed and controlled, the study aims to uncover the causes of congenital heart disease (CHD) and adult cardiovascular conditions. The research utilizes advanced techniques like ATAC sequencing to analyze chromatin accessibility, which helps identify the regulatory networks involved in heart development. Patients may benefit from insights that could lead to new treatments or preventive strategies for heart diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital heart disease and related cardiovascular conditions.
How similar studies have gone: Previous research has shown promise in understanding genetic regulation of heart development, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Black, Brian L — University of California, San Francisco
- Study coordinator: Black, Brian L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.