Understanding how genes are spliced in single-cell RNA data
Official title: Differential exon usage in single cell RNA-seq
Funded at University of Nevada Las Vegas · NIH-11325722 · Data updated 2026-11-12
Aims to improve how we read and use single-cell RNA data to see how different cell types and tissues cut and join genes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $146,206 |
| NIH project number | 5R16GM149510-04 |
| Project ID | NIH-11325722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable (this grant is a computational method development project; no patient participation is required).
✕Less likely to help
No direct patient participation or benefit is involved in this project.
What this research studies
This project examines how alternative RNA splicing varies across cells using short-read single-cell RNA sequencing. It will develop methods to detect differential exon usage from data with low read depth and high noise, and compare different analysis approaches. The team will also benchmark existing tools and validate findings against newer sequencing protocols to improve accuracy for researchers studying cell development and tissue identity.
Why it matters
Potential benefit: If successful, this work could make single-cell splicing analysis more reliable, helping researchers understand cell development and tissue differences.
How similar studies have gone: Previous studies show that careful modeling can improve detection of splicing events in single-cell data, but many methods remain imperfect and this project seeks to advance that.
Where this research is happening
-
University of Nevada Las Vegas
Las Vegas, United States Active
Researchers
- Principal investigator: Han, Mira — University of Nevada Las Vegas
- Study coordinator: Han, Mira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.