Understanding how genes affect opioid use disorders
Transcriptional Regulation In Human Opioid Use Disorders
['FUNDING_P01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10934813
This study is looking at how our genes and brain cells might influence opioid addiction, like with heroin and fentanyl, to help find better treatments for people dealing with opioid use disorders.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10934813 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and epigenetic factors that contribute to opioid use disorders (OUD) by examining specific brain regions involved in reward processing. Using advanced techniques like single nucleus RNA sequencing, researchers will analyze individual cell types in both human and rat brains to understand how opioids like heroin and fentanyl affect these cells differently. The study aims to uncover the molecular mechanisms behind addiction, which could lead to more effective treatments for those struggling with OUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder, particularly those affected by heroin or fentanyl use.
Not a fit: Patients who do not have opioid use disorders or are not involved in opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for individuals suffering from opioid use disorders.
How similar studies have performed: Previous research has shown promise in understanding addiction through genetic studies, but this approach using single-cell analysis in humans is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HURD, YASMIN L. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: HURD, YASMIN L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases