Understanding how genes affect immune cells in Type 1 diabetes
Influence of MHC-II polymorphisms on autoimmune T cell repertoire development and function
This work explores how certain genetic differences influence the immune cells that cause Type 1 diabetes, aiming to find new ways to diagnose and stop the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11132930 on NIH RePORTER |
What this research studies
Type 1 diabetes happens when the body's immune system mistakenly destroys insulin-producing cells in the pancreas, leading to serious health problems. We know that specific genes, called MHC class II genes, strongly increase the risk of developing Type 1 diabetes. This project uses a special mouse model to compare how these risk genes, versus protective genes, shape the immune cells that attack the pancreas. By understanding these differences, we hope to uncover the specific processes that lead to the disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals at risk for or living with Type 1 diabetes.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose Type 1 diabetes earlier and develop treatments that stop the immune attack on the pancreas.
How similar studies have performed: While the specific mouse model is novel, other studies have successfully used genetic models to understand autoimmune disease mechanisms.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Huseby, Eric S — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Huseby, Eric S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.