Understanding how genes affect heart inflammation after a heart attack
Genetic modulation of inflammation following myocardial infarction
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11180330
This research looks at how our genes influence the body's healing process and inflammation after a heart attack.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11180330 on ClinicalTrials.gov |
What this research studies
After a heart attack, the body has an inflammatory response that is important for healing. This research explores how special immune cells, called regulatory T cells (Tregs), help control this inflammation. We know that a specific protein on these cells, called CD39, helps reduce inflammation, and the levels of CD39 are influenced by our genes. This project aims to understand how these genetic differences in CD39 activity affect how well the heart heals and how inflammation resolves after a heart attack.
Who could benefit from this research
Good fit: Patients who have experienced a myocardial infarction (heart attack) and are interested in how genetics influence their recovery might be ideal candidates for future related studies.
Not a fit: Patients without a history of myocardial infarction or those not interested in genetic factors related to heart healing may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to improve heart healing and reduce complications for patients after a heart attack by targeting specific genetic pathways.
How similar studies have performed: While mouse studies have shown the importance of CD39 in heart healing, this specific project is novel in examining the genetic control of Treg CD39 activity and its impact on human cardiac inflammation resolution.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUMINA, RICHARD J — OHIO STATE UNIVERSITY
- Study coordinator: GUMINA, RICHARD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease