Understanding how genes affect heart development and disease
Genetic determinants of 4D genome folding in human cardiac development
This study is looking at how our genes shape the way our heart develops and how changes in these genes can lead to heart problems, with the hope of finding new ways to help patients with congenital heart disease and arrhythmias.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10912741 on NIH RePORTER |
What this research studies
This research investigates the role of genetic factors in the three-dimensional organization of the genome during heart development. By using advanced techniques like ATAC sequencing and machine learning, the study aims to uncover how mutations in specific genes can lead to congenital heart disease and arrhythmias. The research focuses on human cardiac cells, including cardiomyocytes and endothelial cells, to explore the dynamic changes in genome structure that occur during normal and abnormal heart development. Patients may benefit from insights gained about the genetic causes of heart conditions and potential new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with congenital heart disease or those with a family history of heart conditions.
Not a fit: Patients with heart conditions unrelated to genetic factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital heart disease and related conditions.
How similar studies have performed: Other research has shown success in understanding genetic influences on heart development, but this specific approach to 3D genome folding is relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Bruneau, Benoit Gaetan — J. David Gladstone Institutes
- Study coordinator: Bruneau, Benoit Gaetan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.