Understanding how gene networks control heart development and disease
Combinatorial Regulation of Gene Networks During Cardiac Development and Disease
This study is looking at how certain genes work together during heart development and how they might be involved in heart problems like congenital heart defects, with the hope of finding new ways to treat heart diseases that could help patients in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10692594 on NIH RePORTER |
What this research studies
This research investigates the role of specific gene networks and their regulation during heart development and in conditions like congenital heart defects. By utilizing advanced techniques such as CRISPR/Cas9 genome engineering, the team aims to understand how transcription factors and chromatin remodeling influence cardiac gene expression. The study involves a multidisciplinary approach, combining expertise from developmental cardiology and computational biology to explore how these genetic interactions can lead to new regenerative medicine strategies. Patients may benefit from insights that could lead to innovative treatments for heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include adults with congenital heart defects or those at risk for cardiovascular diseases.
Not a fit: Patients with non-cardiovascular related conditions or those without congenital heart defects may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for congenital heart defects and other cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in using gene regulation approaches for cardiac regeneration, indicating potential for success in this area.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Srivastava, Deepak — J. David Gladstone Institutes
- Study coordinator: Srivastava, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.