Understanding how gene changes affect drug-seeking behavior
Epigenetic mechanisms in the medial habenula governing drug-seeking behavior
This study is looking at how changes in the brain can affect cravings for cocaine, with the hope of finding new ways to help people struggling with addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10829409 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic mechanisms in the medial habenula, a brain region, and how these mechanisms influence drug-seeking behavior, particularly in relation to cocaine. By examining the molecular and cellular changes that occur after repeated drug exposure, the study aims to uncover how these changes can lead to persistent addiction behaviors. The research will utilize advanced techniques to analyze gene expression and neuronal function, providing insights into the biological underpinnings of addiction. Patients may benefit from a better understanding of addiction and potential new treatment strategies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine use or those struggling with addiction-related behaviors.
Not a fit: Patients who do not have a history of drug use or are not affected by addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating addiction and preventing relapse.
How similar studies have performed: Other research has shown promising results in understanding the role of epigenetics in addiction, indicating that this approach has potential for significant insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Wood, Marcelo Andres — University of California-Irvine
- Study coordinator: Wood, Marcelo Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.