Understanding how gasdermins are regulated in immune responses.
Official title: Regulation of gasdermins through protease processing and other post-translational modifications.
Funded at Case Western Reserve University · NIH-11031400 · Data updated 2026-11-12
This study is looking at how certain proteins called gasdermins work in the body, especially in people with autoimmune diseases, to help us understand how the immune system reacts to infections and illnesses, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | February 15, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $362,250 |
| NIH project number | 5R35GM152080-02 |
| Project ID | NIH-11031400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune or autoinflammatory disorders.
✕Less likely to help
Patients with non-autoimmune related conditions or those not experiencing inflammatory responses may not benefit from this research.
What this research studies
This research investigates the regulation of gasdermins, proteins involved in inflammatory cell death, particularly in the context of autoimmune and autoinflammatory diseases. The team will explore how gasdermins are processed by various proteases and modified through post-translational changes, which can influence their role in immune signaling. By studying these mechanisms, the research aims to uncover new insights into how the immune system responds to infections and diseases, potentially leading to novel therapeutic strategies. Patients may benefit from a better understanding of their conditions and new treatment options based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage autoimmune and autoinflammatory diseases.
How similar studies have gone: Previous research has shown promise in understanding inflammasome pathways and gasdermin function, indicating potential for success in this area.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Xiao, Tsan Sam — Case Western Reserve University
- Study coordinator: Xiao, Tsan Sam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.