Understanding how fungi change in long-lasting lung infections
Evolved Heterogeneity Contributes to Chronic Fungal Lung Infections
This project looks at how fungi change over time in the lungs of people with cystic fibrosis to better understand chronic infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11122192 on NIH RePORTER |
What this research studies
We are looking closely at how fungi like Candida lusitaniae adapt and change within the lungs of individuals with cystic fibrosis. These fungi can become resistant to treatments and cause ongoing inflammation. By studying samples collected over time, we hope to discover the specific genetic changes that help these fungi survive and resist medicines. This knowledge could help us find new ways to treat these difficult infections, especially since this fungus is related to other drug-resistant pathogens.
Who could benefit from this research
Good fit: This research focuses on understanding fungal infections in individuals with cystic fibrosis who have experienced chronic Candida lusitaniae infections.
Not a fit: Patients without chronic fungal lung infections or those whose infections are not caused by Candida lusitaniae may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat chronic fungal lung infections, especially in patients with cystic fibrosis.
How similar studies have performed: This project builds on initial findings from genomic and phenotypic analysis of these specific fungal populations, suggesting a promising direction for further investigation.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Hogan, Deborah a — Dartmouth College
- Study coordinator: Hogan, Deborah a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.