Understanding how fluid removal affects blood flow during dialysis for kidney injury
Official title: Macrovascular and Microvascular Response to Fluid Removal during Hemodialysis for Acute Kidney Injury
Funded at University of Pennsylvania · NIH-11088708 · Data updated 2026-11-12
This study is looking at how removing fluid during dialysis affects blood flow in people with acute kidney injury, and it aims to find better ways to keep track of fluid levels to help prevent problems like too much fluid or low blood pressure, ultimately making dialysis safer and more tailored to each patient's needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $187,565 |
| NIH project number | 5K23DK129770-05 |
| Project ID | NIH-11088708 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute kidney injury who require hemodialysis.
✕Less likely to help
Patients with chronic kidney disease who are not currently experiencing acute kidney injury may not benefit from this research.
What this research studies
This research investigates the effects of fluid removal during hemodialysis on blood flow in patients with acute kidney injury (AKI). It aims to find better ways to monitor and manage fluid levels to prevent complications like fluid overload or low blood pressure. The study will use advanced technologies to continuously track blood flow and tissue perfusion during dialysis treatments, which could lead to more personalized care for patients. By identifying individual responses to fluid removal, the research seeks to improve patient outcomes during dialysis.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective dialysis treatments for patients with acute kidney injury.
How similar studies have gone: Previous research has shown promise in using continuous monitoring techniques during dialysis, but this specific approach is relatively novel.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Brotman, Christina Hao Wang — University of Pennsylvania
- Study coordinator: Brotman, Christina Hao Wang
Related research
Other NIH-funded projects on the same topics.
-
SEAK Alliance: Improving Care for AKI Patients in the Southeast
A national, patient-centered effort to improve post-hospital care for people who had acute kidney injury in the Southeast.
-
AKI-related delirium after heart surgery
This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.
-
Better ways to identify types of sudden kidney injury in U.S. Veterans
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-
Neuroimmune control of kidney injury using noninvasive ultrasound
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-
Optimizing a prehabilitation program for kidney transplant candidates on dialysis
A program to improve physical function and readiness for kidney transplant in people on dialysis is being developed and tested to help candidates stay healthier while they wait.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.