Understanding how ferroptosis affects cancer cell behavior
Ferroptosis and Cancer Cell Signaling
This study is looking at a special kind of cell death in cancer cells that’s affected by how cells use iron and energy, with the goal of finding new ways to make cancer treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11009002 on NIH RePORTER |
What this research studies
This research investigates a specific type of programmed cell death called ferroptosis, which is influenced by cellular metabolism and iron levels. The study aims to uncover how ferroptosis is regulated in cancer cells, particularly through interactions between cells and signaling pathways. By exploring these mechanisms, the research seeks to identify potential new targets for cancer therapies that could enhance the effectiveness of treatments. Patients may benefit from insights that could lead to more effective anti-cancer strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that may be sensitive to ferroptosis induction.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not influenced by ferroptosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cancer treatment outcomes by targeting ferroptosis.
How similar studies have performed: Other research has shown promising results in targeting cell death pathways in cancer, suggesting that this approach could be effective.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Jiang, Xuejun — Sloan-Kettering Inst Can Research
- Study coordinator: Jiang, Xuejun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.