NIH-funded research Fellowship grant

Understanding how fear can return after treatment for anxiety

Official title: Using latent cause modeling and neurofeedback to understand fear relapse and its relationship to anxiety

Funded at Princeton University · NIH-11165469 · Data updated 2026-11-12

This study is looking at why some people feel anxious again after treatment for anxiety and aims to help improve therapy by understanding how different people react to fear and safety signals.

More Anxiety research and trials

Quick facts

Grant typeFellowship grant
Study typeNIH-funded research
Funding institutionPrinceton University
NIH-funded
Lab location1 site (Princeton, UNITED STATES)
Project startMay 1, 2025
Project endApril 30, 2027
Funding year2025
Award (this year)$76,756
NIH project number1F32MH140486-01
Project IDNIH-11165469 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals with anxiety disorders who have undergone exposure therapy and are experiencing fear relapse.

Less likely to help

Patients who do not have anxiety disorders or those who have not participated in exposure therapy may not benefit from this research.

What this research studies

This research investigates why some individuals experience a return of fear after undergoing exposure therapy for anxiety disorders. By using advanced techniques like latent cause modeling and neurofeedback, the study aims to identify individual differences in how people process fear and safety associations. Participants will engage in tasks designed to reveal their responses to fear and safety cues, helping researchers understand the neural mechanisms behind these responses. The ultimate goal is to improve treatment outcomes for anxiety by addressing the reasons behind fear relapse.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatments for anxiety disorders by reducing the likelihood of fear relapse.

How similar studies have gone: Previous research has shown promising results in understanding fear responses and treatment outcomes, indicating that this approach could yield valuable insights.

Where this research is happening

  • Princeton University
    Princeton, United States
    Active

Researchers

  • Principal investigator: Hennings, Augustin Cole — Princeton University
  • Study coordinator: Hennings, Augustin Cole

Related research

Other NIH-funded projects on the same topics.

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  • Brain electrical signals linked to fear and anxiety

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  • Calming dental visits for children with sensory sensitivities and dental anxiety

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    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11307553

  • Understanding fear and anxiety related to dental care

    This study is looking at how people feel and behave when they think about or go through dental care, especially those who feel anxious or scared, to find better ways to help everyone have a more positive experience at the dentist.

    NIH research University of Florida · Gainesville, United States · NIH-11170446

  • Improving dental care for children with anxiety through sensory adaptations

    This study is looking at how a special dental setting with calming sights and sounds can help make trips to the dentist less scary for kids, especially those who feel anxious or have sensory sensitivities, and it will involve 312 children aged 6 to 12 to see if this approach really helps.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11103364

  • How air pollution affects anxiety and brain function in adolescents

    This study is looking at how air pollution, specifically tiny particles in the air called PM2.5, might affect anxiety and brain function in teenagers, helping us understand how breathing in dirty air could be linked to anxiety problems in young people.

    NIH research Wayne State University · Detroit, United States · NIH-10914655

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.