Understanding how fatty acids and inflammation affect heart disease
Investigating the impact of a fatty acid-cRel inflammatory circuit in atherosclerosis
This study is looking at how inflammation and fat processing in immune cells might affect heart health, especially in people dealing with plaque buildup in their arteries, to help find better ways to manage heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10805441 on NIH RePORTER |
What this research studies
This research investigates the connection between inflammation and lipid metabolism in macrophages, which are immune cells that play a role in heart disease. By using advanced techniques, the study aims to uncover how changes in fatty acid levels can influence inflammatory responses and contribute to atherosclerosis, a condition characterized by the buildup of plaque in arteries. The researchers will explore specific mechanisms that link these processes, potentially leading to new insights into cardiovascular health and disease management.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atherosclerosis or related cardiovascular conditions, particularly those with inflammation-related issues.
Not a fit: Patients without cardiovascular disease or those not experiencing inflammation-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation and lipid levels in patients at risk for heart disease.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between inflammation and lipid metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bensinger, Steven J — University of California Los Angeles
- Study coordinator: Bensinger, Steven J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.