Understanding how fat tissue affects blood flow and muscle function in severe limb ischemia
Official title: Molecular Mechanisms of Intramuscular Adipose Tissue in Chronic Limb Threating Ischemia
Funded at University of Florida · NIH-10901557 · Data updated 2026-11-12
This study is looking at how fat in the muscles affects blood flow and muscle health in people with severe leg circulation problems, hoping to find new ways to help improve leg function for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $33,727 |
| NIH project number | 1F31HL174156-01 |
| Project ID | NIH-10901557 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are diagnosed with chronic limb threatening ischemia.
✕Less likely to help
Patients with conditions unrelated to chronic limb threatening ischemia or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of intramuscular adipose tissue (IMAT) in chronic limb threatening ischemia (CLTI), a severe form of peripheral arterial disease. The study aims to understand how IMAT and fibrosis impact blood vessel growth and muscle function in affected limbs. Using genetic and pharmacologic methods, researchers will manipulate IMAT levels in mice to observe the effects on limb health. The findings could lead to new therapeutic strategies for improving limb function in patients with CLTI.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance blood flow and muscle function in patients suffering from chronic limb threatening ischemia.
How similar studies have gone: While there have been unsuccessful trials with angiogenic therapies in CLTI, this research explores a novel approach by focusing on the role of intramuscular adipose tissue, making it a potentially groundbreaking investigation.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Palzkill, Victoria R — University of Florida
- Study coordinator: Palzkill, Victoria R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.