Understanding how exercise affects liver disease
Mechanistic basis of exercise responses in liver disease
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10909351
This study is looking at how different types of exercise can help people with cirrhosis by improving their muscle strength and overall fitness, while also exploring how gut health might play a role in these benefits.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10909351 on ClinicalTrials.gov |
What this research studies
This research investigates how exercise impacts patients with cirrhosis, particularly focusing on the loss of muscle mass and physical frailty. It aims to uncover the biological mechanisms behind exercise responses in these patients, exploring how different types of exercise can improve muscle mass and exercise capacity. The study will also examine the role of the gut microbiome and metabolites in these responses, as well as the challenges of maintaining adherence to exercise programs. By integrating various scientific approaches, the research seeks to provide insights that could enhance treatment strategies for individuals with liver disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cirrhosis who experience muscle loss and physical frailty.
Not a fit: Patients with liver disease who do not have issues related to muscle mass or exercise capacity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise programs that enhance muscle mass and overall health in patients with liver disease.
How similar studies have performed: Previous research has shown that exercise can improve outcomes in patients with liver disease, but the specific mechanisms in cirrhosis are still being explored.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DASARATHY, SRINIVASAN — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: DASARATHY, SRINIVASAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chronic Disease