Understanding how exercise affects liver disease
Official title: Mechanistic basis of exercise responses in liver disease
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10909351 · Data updated 2026-11-12
This study is looking at how different types of exercise can help people with cirrhosis by improving their muscle strength and overall fitness, while also exploring how gut health might play a role in these benefits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $275,231 |
| NIH project number | 5R01DK133905-02 |
| Project ID | NIH-10909351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cirrhosis who experience muscle loss and physical frailty.
✕Less likely to help
Patients with liver disease who do not have issues related to muscle mass or exercise capacity may not benefit from this research.
What this research studies
This research investigates how exercise impacts patients with cirrhosis, particularly focusing on the loss of muscle mass and physical frailty. It aims to uncover the biological mechanisms behind exercise responses in these patients, exploring how different types of exercise can improve muscle mass and exercise capacity. The study will also examine the role of the gut microbiome and metabolites in these responses, as well as the challenges of maintaining adherence to exercise programs. By integrating various scientific approaches, the research seeks to provide insights that could enhance treatment strategies for individuals with liver disease.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise programs that enhance muscle mass and overall health in patients with liver disease.
How similar studies have gone: Previous research has shown that exercise can improve outcomes in patients with liver disease, but the specific mechanisms in cirrhosis are still being explored.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.