Understanding how exercise affects blood flow in patients with peripheral artery disease
Exercise Pressor Reflex in Peripheral Artery Disease: Roles of Flow Limitation and Reperfusion
This study is looking at how exercise affects blood flow and muscle response in people with peripheral artery disease (PAD) and is testing if a medication called amiloride can help improve walking and reduce the body's strong reaction to exercise in these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10869893 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cardiovascular issues in patients with peripheral artery disease (PAD), particularly focusing on how exercise impacts blood flow and muscle response. The study aims to explore the exaggerated exercise pressor reflex (EPR) observed in PAD patients and how factors like blood flow restriction and ischemia-reperfusion stress contribute to this condition. By using both human and animal models, the researchers will test whether a medication called amiloride can help reduce the exaggerated EPR and improve walking tolerance in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with peripheral artery disease who experience limitations in exercise due to cardiovascular issues.
Not a fit: Patients without peripheral artery disease or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that enhance exercise tolerance and overall cardiovascular health for patients with peripheral artery disease.
How similar studies have performed: Previous research has shown promise in understanding the exercise pressor reflex in cardiovascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Li, Jianhua — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Li, Jianhua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.