Understanding how excess iron harms kidneys in lupus nephritis
Mechanisms of iron-mediated renal injury in lupus nephritis
This study is looking at how too much iron can hurt the kidneys in people with lupus nephritis, and it hopes to find new ways to protect the kidneys while keeping iron levels healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10764830 on NIH RePORTER |
What this research studies
This research investigates the harmful effects of excess iron on kidney health in patients with lupus nephritis, a serious complication of lupus that affects many individuals. The study aims to explore how abnormal iron metabolism contributes to kidney damage and seeks to identify potential new treatment strategies that could protect the kidneys while maintaining healthy iron levels. By examining the mechanisms of iron-related injury, the research hopes to provide insights that could lead to improved therapies for lupus nephritis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lupus nephritis, particularly those experiencing kidney damage related to their condition.
Not a fit: Patients without lupus or those whose kidney function is not affected by lupus nephritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that better protect the kidneys of lupus nephritis patients and improve their overall health outcomes.
How similar studies have performed: Previous studies have shown promising results in understanding the role of iron in kidney injury, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Boesen, Erika Ingrid — University of Nebraska Medical Center
- Study coordinator: Boesen, Erika Ingrid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.