Understanding how evolution shapes human responses to infectious diseases
Translation of evolution-guided insights for new models of human infectious disease
This study looks at how germs change over time and how our immune system reacts to them, especially focusing on a part of our immune system called inflammasomes, to help us find better ways to treat infections and autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11078312 on NIH RePORTER |
What this research studies
This research investigates how the evolution of pathogens influences human immune responses, particularly focusing on inflammasomes, which are critical components of the immune system. By studying the interactions between pathogens and the human immune system, the research aims to develop better models for understanding infectious diseases and autoimmune conditions. The approach combines evolutionary insights with mechanistic studies to uncover how specific pathogens activate immune responses in humans compared to other species. This could lead to improved strategies for treating infections and autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from autoimmune diseases or those with a history of severe infections.
Not a fit: Patients with non-infectious conditions or those not affected by autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for infectious diseases and autoimmune conditions by improving our understanding of human immunity.
How similar studies have performed: Other research has shown success in using evolutionary insights to understand immune responses, indicating that this approach has potential for significant advancements.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Mitchell, Patrick S — University of Washington
- Study coordinator: Mitchell, Patrick S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.