Understanding how Epstein-Barr virus affects Inflammatory Bowel Disease
Genomics of Inflammatory Bowel Disease
This study is looking at how the Epstein-Barr virus might affect the severity of Inflammatory Bowel Disease and why some treatments don’t work for everyone, and it’s for patients with IBD who might be asked to share samples to help us learn more about this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10684936 on NIH RePORTER |
What this research studies
This research investigates the role of Epstein-Barr virus (EBV) in the severity and treatment resistance of Inflammatory Bowel Disease (IBD). By analyzing genetic data and viral interactions, the study aims to uncover how EBV influences the immune response and disease progression in patients with IBD. The methodology includes advanced techniques like chromatin immunoprecipitation with next-generation sequencing to identify specific genetic loci associated with the disease. Patients may be asked to provide samples for genetic analysis to help establish these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Inflammatory Bowel Disease, particularly those experiencing severe symptoms or treatment resistance.
Not a fit: Patients without a diagnosis of Inflammatory Bowel Disease or those who are not infected with Epstein-Barr virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from Inflammatory Bowel Disease.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and viral interactions in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Kottyan, Leah Claire — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Kottyan, Leah Claire
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.