Understanding how eosinophils help fight bacterial infections
Official title: Role of eosinophils during bacterial infection
Funded at Stanford University · NIH-10888381 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called eosinophils helps our body fight off bacterial infections like Salmonella, using mice to learn more about how these cells work in our immune system, which could help us find new ways to treat infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $234,430 |
| NIH project number | 5R21AI178663-02 |
| Project ID | NIH-10888381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with bacterial infections, especially those who may have immune system challenges.
✕Less likely to help
Patients with non-bacterial infections or those not experiencing immune response issues may not benefit from this research.
What this research studies
This research investigates the role of eosinophils, a type of white blood cell, in combating bacterial infections, particularly focusing on Salmonella. The study aims to understand how these cells contribute to the immune response during infections by examining their behavior in specific tissues, such as lymph nodes. By using mouse models, researchers will explore the mechanisms by which eosinophils help control bacterial growth and influence the immune environment. This could lead to new insights into how the body fights infections and the potential for developing new treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating bacterial infections, particularly in patients with compromised immune systems.
How similar studies have gone: Previous research has shown that eosinophils play important roles in immune responses, but this specific investigation into their role against bacterial infections is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Monack, Denise M — Stanford University
- Study coordinator: Monack, Denise M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.