Understanding how electrospray ionization affects biomolecular structures
Official title: Assessing the Biomolecular Structures that Result from Electrospray Ionization
Funded at Baylor University · NIH-10916404 · Data updated 2026-11-12
This study is looking at how a special technique called electrospray ionization changes the shapes of important molecules in our bodies, like sugars and proteins, to help scientists better understand them and improve tests that could lead to better treatments for diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor University NIH-funded |
| Lab location | 1 site (Waco, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $350,000 |
| NIH project number | 5R35GM150464-02 |
| Project ID | NIH-10916404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular signaling and glycan-related disorders.
✕Less likely to help
Patients with conditions unrelated to glycan interactions or cellular signaling may not receive any benefit from this research.
What this research studies
This research investigates how the process of electrospray ionization (ESI) alters the structures of glycans and proteins, which are essential for various biological functions. By using molecular dynamics simulations and mass spectrometry, the team aims to gain insights into the ionization process and improve analytical methods. Patients may benefit from a better understanding of how these biomolecules interact, which could lead to advancements in treatments for diseases related to cellular signaling and communication.
Why it matters
Potential benefit: If successful, this research could enhance the understanding of biomolecular interactions, potentially leading to improved therapies for diseases linked to cellular communication.
How similar studies have gone: Previous research has shown promise in using mass spectrometry and molecular dynamics to study biomolecular interactions, indicating that this approach could yield valuable insights.
Where this research is happening
-
Baylor University
Waco, United States Active
Researchers
- Principal investigator: Gallagher, Elyssia S — Baylor University
- Study coordinator: Gallagher, Elyssia S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.