HOPE-inG: Increasing cervical cancer screening for women with HIV in Ghana
Official title: The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention among Women Living with HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial
Funded at Baylor University · NIH-11535397 · Data updated 2026-11-12
A study tests a home-based HPV self-sampling approach plus a tailored communication plan to help women living with HIV in Ghana get screened more often for cervical cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor University NIH-funded |
| Lab location | 1 site (Waco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $164,797 |
| NIH project number | 3U01CA294757-03S1 |
| Project ID | NIH-11535397 on NIH RePORTER |
Who could benefit from this research
✓Could help
WLWH in Ghana who have access to the participating secondary-level health facilities and can use home-based self-sampling.
✕Less likely to help
Women who cannot access the intervention sites or are unable to perform home-based self-sampling may not benefit.
What this research studies
This project tests a combined home-based HPV self-sampling kit and a 3R communication model (Reframing, Reprioritizing, and Reforming) to boost cervical cancer screening among WLWH in Ghana. It builds on a previous randomized trial showing large screening gains and aims to scale up and sustain adoption within health facilities. The study uses a Type 2 hybrid effectiveness-implementation design to measure both health outcomes and how best to implement the approach in real-world settings. It engages secondary-level health facilities in Ghana and leverages existing relationships to maximize impact. The goal is to improve health system uptake, patient participation, and long-term maintenance of CCS among WLWH.
Why it matters
Potential benefit: If successful, the intervention could substantially increase cervical cancer screening rates among women living with HIV in Ghana, potentially reducing cancer risk and improving health outcomes.
How similar studies have gone: Previous work showed HOPE increased screening from 14.64% to 100% in the trial, supporting the potential effectiveness of this approach.
Where this research is happening
-
Baylor University
Waco, United States Active
Researchers
- Principal investigator: Asare, Matthew — Baylor University
- Study coordinator: Asare, Matthew
Related research
Other NIH-funded projects on the same topics.
-
mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
-
HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
-
CODA-based cervical cancer screening for LMICs using CRISPR and fluorescence
A low-resource, rapid test called CODA uses CRISPR and light signals to detect cervical cancer markers in women in sub-Saharan Africa to improve screening.
-
CODA-based cervical cancer screening in low-resource settings
A new, quick, low-cost test using CRISPR and fluorescence readouts to help screen for cervical cancer in women in sub-Saharan Africa.
-
CATSystem: a digital tool to boost cervical cancer screening and follow-up in Kenya
A digital tracking system helps doctors and patients in Kenya improve cervical cancer screening, treatment referrals, and follow-up, especially for women living with HIV.
-
Enhanced breast and cervical cancer screening in Kenya through implementation science and training
A multi-institution effort to boost breast and cervical cancer screening, follow-up, and treatment in Kenya using hands-on implementation science and training.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.