Understanding how early-life infections affect immune responses in children
Official title: Innate lymphocyte responses to early-life infections
Funded at Scripps Research Institute, the · NIH-11094862 · Data updated 2026-11-12
This study looks at how young children's immune systems fight off Staphylococcus bacteria, which can cause infections, to help find better vaccines and treatments for these illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $460,000 |
| NIH project number | 5R35GM151347-03 |
| Project ID | NIH-11094862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are at risk of Staphylococcus infections.
✕Less likely to help
Patients who are older than 11 years or those who do not have a history of Staphylococcus infections may not benefit from this research.
What this research studies
This research investigates the immune system's response to Staphylococcus bacteria, which are common causes of infections in young children. It focuses on how innate immune cells, which are present in early life, react to these infections and how this differs from the adaptive immune response that develops later. By studying these immune responses, the research aims to uncover important insights that could lead to effective vaccines and treatments for bacterial infections in children.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines against Staphylococcus infections, significantly improving health outcomes for children.
How similar studies have gone: Previous research has shown promise in understanding immune responses to bacterial infections, but this specific approach to studying early-life infections and innate immunity is relatively novel.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Constantinides, Michael George — Scripps Research Institute, the
- Study coordinator: Constantinides, Michael George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.