Understanding how Down syndrome affects saliva production and autoimmune responses
Molecular mechanisms of oral deficiencies in Down syndrome
['FUNDING_R01'] · NEW YORK UNIVERSITY · NIH-11058191
This study is looking into why people with Down syndrome often have issues with saliva production and are more likely to develop autoimmune diseases, like Sjogren’s Disease, by exploring the genetic and immune factors involved.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11058191 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind oral deficiencies and autoimmune disorders in individuals with Down syndrome. It focuses on the relationship between Down syndrome, characterized by an extra chromosome 21, and conditions like Sjogren’s Disease, which affects saliva production. By studying the genetic and inflammatory responses in Down syndrome, the research aims to uncover why these individuals produce less saliva and are more prone to autoimmune diseases. The approach includes analyzing gene expression and immune responses in both human samples and animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those experiencing oral health issues or autoimmune symptoms.
Not a fit: Patients without Down syndrome or those not experiencing any oral deficiencies or autoimmune symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of oral health and autoimmune conditions in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding autoimmune responses in related conditions, suggesting potential for success in this area as well.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LACRUZ, RODRIGO S. — NEW YORK UNIVERSITY
- Study coordinator: LACRUZ, RODRIGO S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases