Understanding how Down syndrome affects bone healing
Official title: Determining cell-specific mechanisms that drive aberrant bone regeneration in Down syndrome
Funded at Texas A&m Agrilife Research · NIH-10654983 · Data updated 2026-11-12
This study is looking at why people with Down syndrome might have trouble healing their bones and how age and gender play a role, with the hope of finding better ways to help them recover from bone injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,633,451 |
| NIH project number | 1RF1AG081812-01 |
| Project ID | NIH-10654983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Down syndrome, particularly those experiencing issues related to bone density and regeneration.
✕Less likely to help
Patients without Down syndrome or those not experiencing bone regeneration issues may not benefit from this research.
What this research studies
This research investigates the specific cellular mechanisms that lead to poor bone regeneration in individuals with Down syndrome. By using mouse models that mimic the condition, the study aims to identify age and sex-related differences in bone healing and mineral density. The researchers will explore how these factors contribute to skeletal injuries and aim to find ways to improve bone regeneration in this population. The findings could provide insights into tailored treatments for individuals with Down syndrome.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone regeneration in individuals with Down syndrome, enhancing their quality of life.
How similar studies have gone: Previous studies using murine models have shown promising results in understanding bone regeneration in Down syndrome, indicating potential for success in this research.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Dawson, Lindsay a — Texas A&m Agrilife Research
- Study coordinator: Dawson, Lindsay a
Related research
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Silencing an Extra Chromosome to Help Down Syndrome and Related Conditions
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Infant Down Syndrome Brain and Behavior Study
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DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s
A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.
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Immune and NGF factors in Alzheimer’s for adults with Down syndrome
This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.