Understanding how DNA Polymerase Theta helps repair UV damage
Uncovering the Mechanistic Role of DNA Pol Theta in UV-Damage Repair
This study is looking at how a special protein called DNA Polymerase Theta helps fix DNA damage from UV rays, which can lead to skin cancer, and it will also check if certain changes in this protein found in cancer patients affect its ability to repair DNA.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island College NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10360128 on NIH RePORTER |
What this research studies
This research investigates the role of DNA Polymerase Theta (POLQ) in repairing DNA damage caused by UV rays, which is a significant factor in the development of skin cancer. By using various biochemical and cellular biology techniques, the study aims to uncover how POLQ repairs specific types of UV-induced DNA lesions and whether it protects the genome or contributes to mutations. The research will also explore how certain variants of POLQ found in cancer patients affect this repair process. The findings could provide insights into the mechanisms of skin cancer development and the protective roles of DNA repair enzymes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of skin cancer or those with genetic variants affecting DNA repair mechanisms.
Not a fit: Patients who do not have skin cancer or related genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new strategies for preventing or treating skin cancer.
How similar studies have performed: This research is novel and explores untested mechanisms related to DNA repair in the context of skin cancer.
Where this research is happening
Providence, United States
- Rhode Island College — Providence, United States (Active)
Researchers
- Principal investigator: Towle-Weicksel, Jamie B. — Rhode Island College
- Study coordinator: Towle-Weicksel, Jamie B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.