Understanding how different types of vascular cells contribute to cardiovascular diseases
Vascular smooth muscle cell heterogeneity and disease
This study is looking at different types of smooth muscle cells in the blood vessels and how they change when people have heart-related issues like atherosclerosis and aneurysms, with the goal of finding new treatments that could help improve health for patients with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10805357 on NIH RePORTER |
What this research studies
This research investigates the diversity of vascular smooth muscle cells and their role in various cardiovascular diseases, such as atherosclerosis and aneurysms. It focuses on how these cells can change their characteristics under disease conditions, potentially leading to harmful effects. By identifying specific subpopulations of these cells that contribute to disease progression, the research aims to develop targeted therapies that could improve patient outcomes. Patients may benefit from new treatment strategies that specifically address the underlying cellular mechanisms of their cardiovascular conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with atherosclerosis, aneurysms, or other related cardiovascular conditions.
Not a fit: Patients with non-cardiovascular diseases or those without significant vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for patients with cardiovascular diseases.
How similar studies have performed: Other research has shown promise in understanding vascular cell behavior in disease, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Simons, Michael — Yale University
- Study coordinator: Simons, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.