Understanding how different types of lipoproteins affect artery health
Lipoprotein Interactions in the Vessel Wall
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10805387
This study is looking at how different types of cholesterol in your blood can affect the buildup of plaque in your arteries, especially for people with type 2 diabetes, to find new ways to help prevent heart problems before they get serious.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10805387 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of low-density lipoproteins (LDL) and high-density lipoproteins (HDL) in the development of atherosclerosis, a condition that can lead to serious cardiovascular diseases. The study focuses on how these lipoproteins interact within the blood vessel walls and how their different subtypes may influence the initiation and progression of atherosclerosis, particularly in individuals with type 2 diabetes. By examining these interactions, the research aims to identify potential new strategies to prevent cardiovascular disease before it becomes advanced.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults, particularly those with type 2 diabetes, who are at higher risk for cardiovascular diseases.
Not a fit: Patients without cardiovascular risk factors or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for atherosclerosis, potentially reducing the risk of heart disease in at-risk populations.
How similar studies have performed: Previous research has shown promising results in understanding lipoprotein interactions, but this specific approach focusing on subspecies in the context of type 2 diabetes is relatively novel.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAH, AMY SANGHAVI — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: SHAH, AMY SANGHAVI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease