Understanding how different types of immune cells behave in acute respiratory distress syndrome (ARDS)
Alveolar macrophage subset ontogeny and differentiation during ARDS
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11128438
This study is looking at how certain immune cells in the lungs, called alveolar macrophages, behave during acute respiratory distress syndrome (ARDS) to see if they can help or hurt patients, with the hope of finding new ways to treat this serious lung condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11128438 on ClinicalTrials.gov |
What this research studies
This research investigates the role of alveolar macrophages, a type of immune cell, in acute respiratory distress syndrome (ARDS), a serious lung condition. The study focuses on how these cells develop and differentiate, particularly during lung injury, and aims to identify specific subsets of these cells that may influence patient outcomes. By using animal models, researchers will explore how these immune cells can either worsen or improve the condition, providing insights that could lead to new treatments for ARDS. The findings could help in understanding the mechanisms behind ARDS and potentially guide the development of therapies targeting these immune cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome.
Not a fit: Patients with chronic respiratory conditions or those not experiencing acute respiratory distress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients suffering from ARDS.
How similar studies have performed: Previous research has shown promise in targeting immune cells for improving outcomes in ARDS, indicating that this approach may be viable.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORRELL, ERIC DOUGLAS — UNIVERSITY OF WASHINGTON
- Study coordinator: MORRELL, ERIC DOUGLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome