Understanding how different types of immune cells affect severe COVID-19 lung injury
Neutrophil Heterogeneity and Immunopathogenesis of COVID-19 ARDS
This study is looking at how certain immune cells called neutrophils might be causing lung problems in people with severe COVID-19, and if you join, you'll help us learn more about these cells to find better treatments for you and others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11017715 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in causing acute respiratory distress syndrome (ARDS) in patients with severe COVID-19. By examining the different populations of neutrophils and their functions, the study aims to uncover how these cells contribute to lung injury and inflammation. The researchers will utilize advanced techniques to analyze the behavior of these immune cells in patients, which could lead to new therapeutic strategies. Patients participating in this research may undergo blood tests and other assessments to help identify the specific neutrophil populations involved in their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized COVID-19 patients who are experiencing or at risk of developing acute respiratory distress syndrome.
Not a fit: Patients with mild COVID-19 symptoms or those who have fully recovered from the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from severe COVID-19 and ARDS.
How similar studies have performed: Other research has shown promising results in understanding immune responses in COVID-19, but this specific focus on neutrophil heterogeneity is relatively novel.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Yan, Jun — University of Louisville
- Study coordinator: Yan, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.