Understanding how different SARS-CoV-2 variants affect COVID-19 outcomes
Core C - Modeling Core
This study is looking at how different COVID-19 variants affect people's health and aims to find clues in our immune responses that could help predict how severe the illness might be, with the hope of discovering better ways to treat COVID-19.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11005778 on NIH RePORTER |
What this research studies
This research investigates the varying clinical outcomes of COVID-19 caused by different variants of the SARS-CoV-2 virus. It aims to identify biomarkers that can predict disease severity and viral replication by analyzing the host's immune response and the interactions between the virus and the host. Using advanced AI-based modeling and network analysis, the study will integrate data from both human and animal studies to uncover the biological processes that influence COVID-19 outcomes. The findings could lead to the development of new therapeutic strategies to better manage COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals infected with SARS-CoV-2, particularly those experiencing varying degrees of symptoms.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting COVID-19 severity and tailored treatments for patients.
How similar studies have performed: Other research has shown promise in using AI and network modeling to predict disease outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Garcia-Sastre, Adolfo — Icahn School of Medicine at Mount Sinai
- Study coordinator: Garcia-Sastre, Adolfo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.