Understanding how different immune cells interact in rheumatoid arthritis
DISSECTING THE SPATIAL HETEROGENEITY OF SYNOVIAL INFLAMMATION IN RHEUMATOID ARTHRITIS
This study is looking at how different immune cells work together in the joints of people with rheumatoid arthritis to better understand the disease and find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11031549 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between various immune cell types in the synovium of patients with rheumatoid arthritis (RA). By analyzing high-dimensional spatial datasets, the study aims to identify 'functional units' of co-localizing cells that may contribute to the disease's clinical variability. The approach utilizes advanced statistical tools and artificial intelligence to categorize tissue samples and understand how these cellular aggregates differ across disease subtypes. This could lead to improved disease classification and new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who are experiencing varying degrees of disease severity.
Not a fit: Patients with other types of arthritis or those without a confirmed diagnosis of rheumatoid arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for patients with rheumatoid arthritis.
How similar studies have performed: Previous research has shown promise in using spatial analysis and AI to understand immune responses in various diseases, suggesting that this approach could yield valuable insights in rheumatoid arthritis as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Reshef, Yakir Abraham — Brigham and Women's Hospital
- Study coordinator: Reshef, Yakir Abraham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.