Understanding how different immune cells interact in rheumatoid arthritis
Official title: DISSECTING THE SPATIAL HETEROGENEITY OF SYNOVIAL INFLAMMATION IN RHEUMATOID ARTHRITIS
Funded at Brigham and Women's Hospital · NIH-11031549 · Data updated 2026-11-12
This study is looking at how different immune cells work together in the joints of people with rheumatoid arthritis to better understand the disease and find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $170,101 |
| NIH project number | 1K08AR085165-01 |
| Project ID | NIH-11031549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who are experiencing varying degrees of disease severity.
✕Less likely to help
Patients with other types of arthritis or those without a confirmed diagnosis of rheumatoid arthritis may not benefit from this research.
What this research studies
This research investigates the complex interactions between various immune cell types in the synovium of patients with rheumatoid arthritis (RA). By analyzing high-dimensional spatial datasets, the study aims to identify 'functional units' of co-localizing cells that may contribute to the disease's clinical variability. The approach utilizes advanced statistical tools and artificial intelligence to categorize tissue samples and understand how these cellular aggregates differ across disease subtypes. This could lead to improved disease classification and new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for patients with rheumatoid arthritis.
How similar studies have gone: Previous research has shown promise in using spatial analysis and AI to understand immune responses in various diseases, suggesting that this approach could yield valuable insights in rheumatoid arthritis as well.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Reshef, Yakir Abraham — Brigham and Women's Hospital
- Study coordinator: Reshef, Yakir Abraham
Related research
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-
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This study follows people with rheumatoid arthritis to understand who develops lung disease and what biomarkers predict it.
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This research seeks to understand why some women’s rheumatoid arthritis improves during pregnancy and how to predict and mimic that effect to make treatments safer and more effective for pregnant patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.