Understanding how different dietary fibers affect gut bacteria
Official title: Glycan Utilization Profiling in Human Gut Microbiomes of Common Funds Data
Funded at University of Nebraska Lincoln · NIH-11126988 · Data updated 2026-11-12
This study is looking at how different types of dietary fibers affect the bacteria in our gut, which can help prevent health issues like obesity and heart disease, and it aims to create a tool that gives personalized nutrition advice based on each person's unique gut bacteria.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | June 10, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $294,432 |
| NIH project number | 1R03OD039979-01 |
| Project ID | NIH-11126988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in improving their gut health or those at risk for metabolic diseases who are open to dietary changes.
✕Less likely to help
Patients with established dietary restrictions or those who are not interested in dietary modifications may not benefit from this research.
What this research studies
This research investigates the role of dietary fibers in shaping the gut microbiome, which is crucial for preventing metabolic diseases like obesity and cardiovascular issues. By analyzing data from various human gut microbiomes, the project aims to develop a bioinformatics tool that profiles how different individuals' gut bacteria utilize carbohydrates. This personalized approach to nutrition could lead to tailored dietary recommendations based on an individual's unique microbiome composition. The study will leverage existing data from multiple NIH-funded projects to ensure a diverse representation of populations.
Why it matters
Potential benefit: If successful, this research could lead to personalized dietary interventions that improve gut health and reduce the risk of metabolic diseases.
How similar studies have gone: Previous research has shown promising results in using microbiome data to inform personalized nutrition strategies, indicating that this approach has potential for success.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Yin, Yanbin — University of Nebraska Lincoln
- Study coordinator: Yin, Yanbin
Related research
Other NIH-funded projects on the same topics.
-
Identify Unknowns with Long-Read Bioinformatics for Vet Diagnostic Labs
A hands-on training program using long-read sequencing data to help veterinary diagnostic labs improve pathogen detection and outbreak response.
-
Enhancing pathogen and AMR detection with a new sequencing instrument
A veterinary lab is getting a high-throughput sequencing machine to help detect drug-resistant bacteria and emerging pathogens in animals and food, improving public health readiness.
-
How childhood hardship and neighborhood features affect adult alcohol and tobacco misuse
This project looks at whether adults who experienced tough childhoods are more likely to misuse alcohol or tobacco later in life and whether where they live makes that risk higher or lower.
-
Nicotine's effect on drinking sweetened alcoholic drinks
This project looks at whether nicotine makes people drink more sweetened alcoholic drinks, especially among people who smoke or drink heavily.
-
MiRNA roles in age-related muscle loss and NMJ health
This project explores how small RNA molecules called miRNAs influence muscle aging and the neuromuscular junction in adults.
-
MG53 protein to protect aging muscles during disuse
A small research project will explore whether increasing MG53 protein can help prevent muscle loss during periods of inactivity in aging, with the goal of protecting muscle health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.