Understanding how different brain pathologies affect Alzheimer's disease.
Project 4: Integrative analysis of spatial molecular features and clinico-pathological characteristics
This study is looking at how different brain conditions, like Alzheimer's and Lewy Bodies, affect thinking and memory in older adults by examining brain tissue from 300 people, so we can better understand what makes Alzheimer's worse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10935943 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between various brain pathologies, such as Alzheimer's disease and other conditions like Lewy Bodies, in older adults. By analyzing brain tissue from a diverse group of 300 individuals, the project aims to uncover how these co-occurring conditions impact cognitive decline. The study utilizes advanced techniques, including single nucleus RNA sequencing, to explore the molecular features of brain cells and their relationship to cognitive performance. This comprehensive approach will help identify critical factors that contribute to Alzheimer's disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients who are younger or do not have any cognitive impairments or neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for Alzheimer's disease and related conditions.
How similar studies have performed: Previous research has shown promise in understanding the interactions of multiple brain pathologies, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.