Understanding how different brain pathologies affect Alzheimer's disease.
Official title: Project 4: Integrative analysis of spatial molecular features and clinico-pathological characteristics
Funded at Columbia University Health Sciences · NIH-10935943 · Data updated 2026-11-12
This study is looking at how different brain conditions, like Alzheimer's and Lewy Bodies, affect thinking and memory in older adults by examining brain tissue from 300 people, so we can better understand what makes Alzheimer's worse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,591,238 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who may be experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
✕Less likely to help
Patients who are younger or do not have any cognitive impairments or neurological conditions may not benefit from this research.
What this research studies
This research investigates the complex interactions between various brain pathologies, such as Alzheimer's disease and other conditions like Lewy Bodies, in older adults. By analyzing brain tissue from a diverse group of 300 individuals, the project aims to uncover how these co-occurring conditions impact cognitive decline. The study utilizes advanced techniques, including single nucleus RNA sequencing, to explore the molecular features of brain cells and their relationship to cognitive performance. This comprehensive approach will help identify critical factors that contribute to Alzheimer's disease progression.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for Alzheimer's disease and related conditions.
How similar studies have gone: Previous research has shown promise in understanding the interactions of multiple brain pathologies, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.