Understanding how different brain cells contribute to electrical signals in the brain
Dissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-types
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10338619
This study is looking at how different brain cells create electrical signals, using special imaging techniques in mice, to help us better understand how the brain works and how it might be affected by disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10338619 on ClinicalTrials.gov |
What this research studies
This research investigates the origins of electrical signals in the brain by using advanced imaging techniques to observe how various types of brain cells contribute to these signals. By employing genetically targeted fluorescent voltage indicators in specially bred mice, the team aims to identify the specific roles of different neuron types in generating cortical field potentials. The study combines optical imaging with traditional electrical recordings to provide a comprehensive view of brain activity. This innovative approach could lead to a better understanding of brain function and disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions that affect brain function.
Not a fit: Patients with conditions unrelated to brain function or those who do not have access to the required genetic mouse models may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and potentially lead to new treatments for neurological disorders.
How similar studies have performed: Other research has shown success with similar imaging techniques in understanding brain activity, making this approach promising yet innovative.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNITZER, MARK J — STANFORD UNIVERSITY
- Study coordinator: SCHNITZER, MARK J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders, Encephalon Diseases, Intracranial CNS Disorders, Intracranial Central Nervous System Disorders