Understanding how different bone marrow environments affect blood cell formation
Official title: Heterogeneity of bone marrow cavities shaping the hematopoietic microenvironment
Funded at Massachusetts General Hospital · NIH-10991027 · Data updated 2026-11-12
This study is looking at how different parts of the bone marrow help make blood cells, especially in people with acute myeloid leukemia, to better understand how these areas might affect the disease and how well treatments work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $643,213 |
| NIH project number | 5R01HL166266-02 |
| Project ID | NIH-10991027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute myeloid leukemia who are 21 years or older.
✕Less likely to help
Patients with other types of leukemia or blood disorders unrelated to acute myeloid leukemia may not receive benefit from this research.
What this research studies
This research investigates the role of various bone marrow cavities in supporting blood cell formation, particularly focusing on how different types of stromal cells within these cavities contribute to the hematopoietic microenvironment. By utilizing advanced imaging techniques, the study aims to profile these stromal cells and their functions in relation to acute myeloid leukemia. Patients may benefit from insights gained about how specific bone marrow environments influence disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating acute myeloid leukemia by targeting specific bone marrow environments.
How similar studies have gone: Previous research has shown promising results in understanding the bone marrow microenvironment's role in blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Lin, Charles P. — Massachusetts General Hospital
- Study coordinator: Lin, Charles P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.