Understanding how diet and gut bacteria affect the immune system and autoimmune diseases
Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11087715
This study is looking at how the bacteria in your gut, which are affected by what you eat, can influence your immune system and potentially help manage autoimmune diseases like inflammatory bowel disease and multiple sclerosis, so you can learn how your diet might improve your health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11087715 on ClinicalTrials.gov |
What this research studies
This research investigates how the gut microbiome, influenced by diet, affects immune responses related to autoimmune diseases. It focuses on specific gut bacteria that can activate immune cells, particularly T helper 17 (Th17) cells, which are linked to conditions like inflammatory bowel disease and multiple sclerosis. By exploring the interactions between dietary factors and gut bacteria, the study aims to uncover mechanisms that could lead to new dietary strategies for managing autoimmune conditions. Patients may benefit from insights into how their diet can influence their immune health and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases such as inflammatory bowel disease or multiple sclerosis.
Not a fit: Patients without autoimmune conditions or those not affected by gut microbiome-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that help manage or prevent autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of diet and microbiome interactions in immune responses, suggesting potential for success in this area.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALEXANDER, MARGARET ROSE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: ALEXANDER, MARGARET ROSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder