Understanding how diabetes affects heart disease risk
Official title: Predicting Cardiovascular Outcomes Using Diabetes-Induced Transcriptomic Networks
Funded at University of Connecticut Sch of Med/dnt · NIH-11095878 · Data updated 2026-11-12
This study is looking at how type 2 diabetes might affect heart health by examining certain genes and immune cells in patients, with the goal of finding a better way to spot people who are at higher risk for heart problems so they can get the right help.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $57,538 |
| NIH project number | 5F30HL168980-03 |
| Project ID | NIH-11095878 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may be at risk for cardiovascular disease.
✕Less likely to help
Patients without a diagnosis of type 2 diabetes or those who do not have cardiovascular disease risk factors may not benefit from this research.
What this research studies
This research investigates the relationship between type 2 diabetes and cardiovascular disease by analyzing specific genetic markers in patients. It focuses on how certain immune cells, known as monocytes, behave differently in diabetic patients, potentially leading to increased heart disease risk. By developing a new prediction model based on these genetic signatures, the research aims to better identify individuals at high risk for cardiovascular complications. This could lead to more targeted interventions for those most in need.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing cardiovascular disease in patients with diabetes.
How similar studies have gone: Previous research has shown promise in using genetic markers to predict cardiovascular risk, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Karlinsey, Keaton — University of Connecticut Sch of Med/dnt
- Study coordinator: Karlinsey, Keaton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.