Understanding how dendrites influence neuron activity
Official title: Reexamining the Role of Dendrites in Neuronal Function
Funded at Columbia Univ New York Morningside · NIH-10897216 · Data updated 2026-11-12
This study is looking at how parts of brain cells called dendrites do more than just receive signals; they can also create their own signals that influence how the brain works, which could help us understand and treat neurological disorders better in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,486,982 |
| NIH project number | 5RM1NS132981-02 |
| Project ID | NIH-10897216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurological disorders or conditions affecting brain function.
✕Less likely to help
Patients with purely peripheral nervous system disorders or those without neurological conditions may not receive benefit from this research.
What this research studies
This research investigates the role of dendrites in neurons, challenging the traditional view that they only receive signals. By using advanced techniques like holographic optogenetics and 3D imaging, the team aims to explore how dendrites can generate local spikes that affect neuronal output. The study will involve a collaborative effort among various laboratories to gather data on dendritic function during sensory stimulation. Patients may benefit from insights into neuronal behavior that could inform future treatments for neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and treatments for neurological conditions by revealing how dendrites contribute to brain function.
How similar studies have gone: While the role of dendrites has been studied, this approach using holographic optogenetics and 3D imaging represents a novel and untested methodology.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Yuste, Rafael — Columbia Univ New York Morningside
- Study coordinator: Yuste, Rafael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.