How RNA binding proteins shape when and how genes are used
Official title: How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changes
Funded at Columbia Univ New York Morningside · NIH-11529990 · Data updated 2026-11-12
A research project at Columbia aims to map how RNA binding proteins interact with RNAs to control gene activity, with potential insights for diseases involving gene regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $239,000 |
| NIH project number | 3R35GM152258-03S1 |
| Project ID | NIH-11529990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with conditions involving abnormal RNA regulation or related cellular processes where RBPs may play a role.
✕Less likely to help
People without diseases related to RNA regulation may not directly benefit from this mechanistic study.
What this research studies
This project studies RNA binding proteins (RBPs), which help decide which RNAs are made and how they behave in cells. Researchers will look at how different RBPs interact with RNA and with each other to regulate gene expression during normal development and in disease. They plan to develop methods to measure many RBP interactions at once, so we can understand their networks in complex cellular contexts. The ultimate goal is to link these molecular interactions to changes in cell fate and disease processes. This work could pave the way for targeted approaches to modulate RNA-based regulation in human conditions.
Why it matters
Potential benefit: If successful, findings could lead to new approaches to treat diseases where RNA regulation goes awry.
How similar studies have gone: Similar studies have shown that mapping RBP networks can reveal key regulators of gene expression, supporting the potential value of this approach.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Jovanovic, Marko — Columbia Univ New York Morningside
- Study coordinator: Jovanovic, Marko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.