Understanding how COPD affects muscle function and metabolism
Official title: Metabolic regulation of hypercapnic chronic obstructive pulmonary disease (COPD)-driven skeletal muscle dysfunction
Funded at Albany Medical College · NIH-10991302 · Data updated 2026-11-12
This study is looking into how high carbon dioxide levels in people with COPD can lead to muscle weakness and tiredness, and it hopes to find ways to help improve muscle strength and overall well-being for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | December 15, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $492,774 |
| NIH project number | 5R01HL160661-04 |
| Project ID | NIH-10991302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic obstructive pulmonary disease (COPD) who experience muscle dysfunction and hypercapnia.
✕Less likely to help
Patients with COPD who do not exhibit muscle dysfunction or hypercapnia may not benefit from this research.
What this research studies
This research investigates the mechanisms behind muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD) who experience high levels of carbon dioxide in their blood. It aims to explore how abnormal cellular metabolism contributes to muscle weakness and fatigue in these patients. By studying an animal model, the researchers will focus on specific proteins involved in energy production and how their regulation is altered in COPD. The ultimate goal is to identify potential strategies to improve muscle function and overall quality of life for COPD patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve muscle function and survival rates for patients with COPD.
How similar studies have gone: While the specific mechanisms being investigated are novel, previous research has shown that addressing metabolic dysfunction can improve outcomes in similar patient populations.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Jaitovich, Adolfo Ariel — Albany Medical College
- Study coordinator: Jaitovich, Adolfo Ariel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.