Understanding how congenital Zika affects children over time in Brazil
Official title: Clinical progression and predictors of outcomes in congenital Zika syndrome
Funded at Research Triangle Institute · NIH-11518031 · Data updated 2026-11-12
This project follows children with congenital Zika syndrome in Brazil to learn what factors influence their health and development as they grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $264,473 |
| NIH project number | 3R01HD112407-03S1 |
| Project ID | NIH-11518031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with congenital Zika syndrome, now in middle childhood, who have been followed since birth (up to 11 years old in this study).
✕Less likely to help
Children without CZS or not enrolled in this longitudinal cohort may not directly benefit from this study.
What this research studies
Researchers will track 187 children with congenital Zika syndrome to see how their brain, eyes, bones, mental health, and overall development change over time. The study adds imaging, EEG, and heart-rate measures to better capture neurological and developmental progress. By analyzing malleable predictors, the team hopes to identify factors that improve or worsen outcomes and inform care strategies for families. The work builds on an established Brazilian-U.S. collaboration and focuses on long-term medical and developmental outcomes for these children and their families.
Why it matters
Potential benefit: Better understanding of what can improve outcomes for children with congenital Zika syndrome and how to tailor care as they grow.
How similar studies have gone: This large, longitudinal cohort in CZS with innovative measures is building on prior work and aims to strengthen knowledge where some studies have shown progress in specific domains.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Wheeler, Anne Caroline — Research Triangle Institute
- Study coordinator: Wheeler, Anne Caroline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.