Understanding how cohesin proteins influence brain development and function
Official title: Linking the molecular operations of cohesin to its physiological activity in the mammalian brain
Funded at University of California, San Francisco · NIH-10944724 · Data updated 2026-11-12
This study is looking at how certain proteins help organize our genes and influence brain development, focusing on specific types of nerve cells in mice, to better understand how our brains work and connect.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $619,474 |
| NIH project number | 1R01NS138619-01 |
| Project ID | NIH-10944724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to brain development or neurological disorders.
✕Less likely to help
Patients with fully developed and functioning neural systems without any neurological conditions may not benefit from this research.
What this research studies
This research investigates the role of cohesin proteins in organizing the genome and regulating gene expression in the mammalian brain. By studying mouse olfactory sensory neurons and serotonergic neurons, the research aims to uncover how cohesin and its associated proteins contribute to the development of the central nervous system and the diversity of neuronal cell surfaces. The approach involves examining the dynamics of cohesin in vivo to understand its impact on neural wiring and circuit assembly, which is crucial for brain function.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development and potential therapeutic targets for neurological disorders.
How similar studies have gone: Other research has shown success in understanding the role of cohesin in cellular processes, making this approach promising but still exploring novel aspects in brain development.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Canzio, Daniele — University of California, San Francisco
- Study coordinator: Canzio, Daniele
Related research
Other NIH-funded projects on the same topics.
-
How cancer cells use exosomes to evade the immune system
This study is looking at how cancer cells use tiny bubbles called exosomes to hide proteins that can keep your immune system from fighting the tumor, and by figuring this out, the researchers hope to help doctors understand why some people respond well to cancer treatments while others don’t, ultimately aiming to creat
-
Reducing harm from smoking using electronic cigarettes
This study is looking at whether using electronic cigarettes can be a safer option for people who smoke traditional cigarettes, by comparing the health effects and exposure to harmful substances between the two.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
Cutaneous opioid signals in skin inflammation
A mentor-identified clinician-researcher at UCSF is studying how natural skin opioids regulate itch and pain in inflammatory skin conditions like eczema and hidradenitis, with plans to map where these opioids come from and how they affect skin nerves.
-
Pooling international data to understand long-term bisphosphonate use and atypical femur fractures
This project combines large patient datasets from multiple countries to understand how long-term bisphosphonate use relates to rare hip and thigh bone fractures, helping doctors and patients make safer treatment choices.
-
Airway cell and immune cell talks in lung transplant failure
This grant tests how airway cells and immune cells interact to drive chronic rejection after lung transplant, with the goal of slowing or preventing scar-like damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.