Understanding how cohesin proteins influence brain development and function
Linking the molecular operations of cohesin to its physiological activity in the mammalian brain
This study is looking at how certain proteins help organize our genes and influence brain development, focusing on specific types of nerve cells in mice, to better understand how our brains work and connect.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10944724 on NIH RePORTER |
What this research studies
This research investigates the role of cohesin proteins in organizing the genome and regulating gene expression in the mammalian brain. By studying mouse olfactory sensory neurons and serotonergic neurons, the research aims to uncover how cohesin and its associated proteins contribute to the development of the central nervous system and the diversity of neuronal cell surfaces. The approach involves examining the dynamics of cohesin in vivo to understand its impact on neural wiring and circuit assembly, which is crucial for brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to brain development or neurological disorders.
Not a fit: Patients with fully developed and functioning neural systems without any neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development and potential therapeutic targets for neurological disorders.
How similar studies have performed: Other research has shown success in understanding the role of cohesin in cellular processes, making this approach promising but still exploring novel aspects in brain development.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Canzio, Daniele — University of California, San Francisco
- Study coordinator: Canzio, Daniele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.