Understanding how circular RNAs affect immune responses and brain development
Role of Circular RNAs in Innate Immunity and Neuro-development
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10466836
This study is looking at special RNA molecules called circular RNAs to see how they help our immune system and brain development, which could lead to better ways to manage conditions like autoimmune diseases and cancer, ultimately helping patients stay healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10466836 on ClinicalTrials.gov |
What this research studies
This research investigates the role of circular RNAs (circRNAs) in regulating innate immunity and neuro-development. By studying these unique RNA molecules, the research aims to understand how they influence the immune response to infections and stress signals, which is crucial for maintaining health. The study utilizes advanced sequencing technologies and computational methods to identify and characterize circRNAs, particularly in the context of diseases like autoimmunity and cancer. Patients may benefit from insights gained about how immune responses can be better controlled to prevent chronic inflammation and its effects on brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune conditions, neurodevelopmental disorders, or those affected by chronic inflammation.
Not a fit: Patients with acute infections or those not experiencing immune dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing autoimmune diseases and improving brain health.
How similar studies have performed: Other research has shown promising results in understanding the role of non-coding RNAs in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, RUI — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ZHOU, RUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, bacteria infection, bacterial disease, Cancers, neoplasm/cancer