Understanding how circular DNAs contribute to cancer development
Official title: Investigating the roles of oncogenic extrachromosomal circular DNAs in cancer
Funded at Sloan-Kettering Inst Can Research · NIH-10889276 · Data updated 2026-11-12
This study is looking at how special circular DNA pieces in cancer cells might help tumors grow and become tougher against treatments, and it's designed for anyone interested in understanding more about cancer and finding better ways to fight it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $538,349 |
| NIH project number | 5R01CA282913-02 |
| Project ID | NIH-10889276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with advanced cancers that exhibit aggressive characteristics or drug resistance.
✕Less likely to help
Patients with early-stage cancers or those not exhibiting oncogenic amplification may not benefit from this research.
What this research studies
This research investigates the role of extrachromosomal circular DNAs (ecDNAs) in cancer, focusing on how these circular DNA structures can lead to increased oncogene expression and tumor evolution. By utilizing advanced genetic engineering techniques and mouse models, the study aims to track and manipulate ecDNAs to understand their dynamics during tumor formation and progression. The research seeks to uncover the mechanisms by which ecDNAs contribute to drug resistance and aggressive cancer phenotypes, providing insights into potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating aggressive cancers by targeting the mechanisms driven by ecDNAs.
How similar studies have gone: Previous research has shown promise in understanding the role of circular DNAs in cancer, but this specific approach is relatively novel and untested.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Ventura, Andrea — Sloan-Kettering Inst Can Research
- Study coordinator: Ventura, Andrea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.