Understanding how cholesterol affects blood vessel inflammation
Official title: Membrane cholesterol and vascular inflammation
Funded at University of California Los Angeles · NIH-11065356 · Data updated 2026-11-12
This study is looking at how cholesterol affects heart health and inflammation in blood vessels, with the goal of helping patients understand how managing cholesterol can improve their cardiovascular conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $773,259 |
| NIH project number | 1R01HL175240-01A1 |
| Project ID | NIH-11065356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to high cholesterol or cardiovascular diseases.
✕Less likely to help
Patients without cardiovascular risk factors or those who do not have elevated cholesterol levels may not benefit from this research.
What this research studies
This research investigates the cellular pathways that regulate cholesterol levels and their impact on cardiovascular diseases. It focuses on how cholesterol transport mechanisms influence vascular inflammation, particularly in endothelial cells. By identifying proteins that respond to cholesterol changes, the study aims to uncover new insights into how cholesterol accumulation can affect blood vessel health and inflammation. Patients may benefit from a better understanding of how cholesterol management can influence cardiovascular conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases linked to cholesterol and inflammation.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between cholesterol and vascular inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Tontonoz, Peter J — University of California Los Angeles
- Study coordinator: Tontonoz, Peter J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.